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. 2021 Aug 11;24(9):102967. doi: 10.1016/j.isci.2021.102967

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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YAP regulates alveolar epithelial cell differentiation

(A–C) Immunofluorescence analysis of proliferation (KI67), AT1 (HOPX, AGER), AT2 (SFTPC, SFTPB), and epithelial (NKX2.1) cell markers to assess alveolar epithelial cell proliferation and differentiation in YAP^active and YAP^deleted mouse lungs.

(D) Quantification of HOPX+/SFTPC- AT1, HOPX-/SFTPC+ AT2, HOPX+/SFTPC+ “dual positive” (yellow arrow) and KI67+/SFTPC+ proliferating AT2 cells (red arrows) in PND14 (N = 11 WT, 12 YAP^active, 10 YAP^deleted), 28 (N = 9 WT, 9 YAP^active, 8 YAP^deleted), and 90 (N = 8 WT, 8 YAP^active, 8 YAP^deleted). SFTPC+ “doublets” are indicated with white arrows. Whiskers of box-whisker plots represent min and max values. ∗Indicates p<0.05 as determined by Two-way ANOVA followed by Sidak's multiple comparisons test.