Fig. 1.

Construction and validation of M2 macrophage-related clusters based on machine learning. A, clustering dendrogram demonstrating good separation of the two clusters determined via PAM algorithm by traits. B, sample clustering by PCA in the TCGA dataset. C, Kaplan-Meier survival analysis of the two clusters. D, validation of clustering by pamr. E, selection of optimal threshold and exhibition of misclassification error. F, heatmap illustrating the differentiation power of 13 genes, red dots and green dots representing samples classified by genes. G, validation of clustering by neural network. H, validation of clustering by SVM. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)