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. 2021 Aug 10;12:705999. doi: 10.3389/fimmu.2021.705999
GEJ gastric/esophagogastric junction
CRC colorectal cancer
EC esophageal cancer
GC gastric cancer
ESCC esophageal squamous cell carcinoma
SCC esophageal adenocarcinoma
CRT chemoradiotherapy
TNM tumor node metastasis
CAR-T chimeric antigen receptor-therapy
EGFR2 epidermal growth factor receptor 2
TAMs tumor-associated macrophages
IFN interferon
IL interleukin
TCR T cell receptor
BCR B cell receptor
MHC major histocompatibility complex
NK cell natural killer cell
DCs dendritic cells
CTLA-4 cytotoxic T-lymphocyte-associated protein 4
LAG-3 lymphocyte activation gene 3
ASCO American Society of Clinical Oncology
TIM-3 T cell immunoglobulin 3
PD-1 programmed cell death 1
PD-L1 programmed cell death ligand 1
ACT adoptive cell therapy
NKT cell natural killer T cell
IDO indoleamine 2,3-dioxygenase
MSI microsatellite instability
MSS microsatellite stability
dMMR defective match repair
pMMR proficient match repair
ORR objective response rate
EBV Epstein-Barr virus
APC antigen-presenting cell
CMS 1-4 consensus molecular subtype 1-4
TGF-β transforming growth factor β
TNF-α tumor necrosis factor α
GM-CSF granulocyte-macrophage colony stimulating factor
Mst1 macrophage stimulator 1
CCL2/CCR2 C-C motif chemokine ligand 2/C-C motif chemokine ligand 2 receptor
CSF1R colony stimulating factor-1 receptor
KIRs killer-cell immunoglobulin-like receptors
NKG2A CD94/NK group 2 member A
HLA leukocyte antigen
TME tumor microenvironment
TIME tumor immune microenvironment
MDSCs myeloid derived suppressor cells
CDR3 complementarity determining region 3
ADCP antibody-dependent cellular phagocytosis
CEA carcino-embryonic antigen
HER2 human epidermal growth factor receptor-2
GPC3 complement C3 protein
EpCAM epithelial cell adhesion molecule
EGFR epidermal growth factor receptor
VEGF vascular endothelial growth factor
SIRPα signal regulatory protein-α
PLR platelet-lymphocyte ratio
TAP2 ATP binding cassette subfamily B member 3
ICI immune checkpoint inhibitor therapy
ECM extracellular matrix
TILs tumor infiltrating lymphocytes
CAFs cancer-associated fibroblasts
EGF epidermal growth factor
Breg cells regulatory B cells
Treg cells regulatory T cells
RCC renal cell carcinoma
CEA carcinoembryonic antigen
ROS reactive oxygen species
RNS reactive nitrogen species
MMP9 matrix metalloproteinase 9
NETs neutrophil extracellular traps
MSI-H microsatellite instability-high
iNKT cells invariant natural killer T cells
PFS progression-free survival
OS overall survival