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. 2021 Aug 10;9:714716. doi: 10.3389/fcell.2021.714716

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Copyright © 2021 Woods and Guezguez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed MSC lineage tree derived from recent sc-RNA sequencing experiments from murine stroma. Mesenchymal progenitor cells give rise to either adipo-primed MSC or an osteochondro-progenitor, which in turn gives rise to osteo-primed or chondro-primed MSC. Noted beside each entity are the most defining upregulated genes. Figure was generated using Biorender.com.