TABLE 4.
Interim data on canine characteristics, viral dosing, tumor pathology, and survival after administration of M032
| ID No. |
Age at Treatment (yrs) |
Weight at Treatment (kg) |
Sex-Neuter, Spay, or Intact |
Breed | Tumor Location |
Prior Treatment |
M032 Dose (pfu) |
Tumor Pathology |
Tumor Grade |
Posttreatment Survival (days) |
|---|---|---|---|---|---|---|---|---|---|---|
| 001 | 6 | 14.1 | M-N | English Bulldog | Lt frontal/parietal lobe | No | 1E+06 | Oligodendroglioma | Low | 108 |
| 002 | 10 | 24.1 | M-N | Boxer | Rt frontal lobe | No | 1E+06 | Oligodendroglioma | High | 372 |
| 003 | 7 | 23.0 | M-N | English Bulldog | Lt parietal/occipital lobe | No | 1E+06 | Oligodendroglioma | High | 232 |
| 004 | 9 | 7.03 | M-N | Yorkshire Terrier | Rt frontal lobe | Yes | 1E+07 | Astrocytoma | Low | 188 |
| 005 | 7 | 53.0 | M-N | Mixed breed | Lt piriform lobe | Yes | 1E+07 | Oligodendroglioma | High | 151 |
| 006 | 6 | 10.8 | M-N | Boston Terrier | Rt forebrain | No | 1E+07 | Astrocytoma | Undetermined | 415 |
| 007 | 7 | 12.7 | M-N | Mixed breed | Rt rostral fossa | No | 1E+08 | Oligodendroglioma | Undetermined | Left study to pursue alternate treatment |
| 008 | 6 | 55.2 | F-S | German Shepherd | Rt frontal lobe | No | 1E+08 | Oligodendroglioma | High | 41 |
| 009 | 11 | 8.6 | F-S | Boston Terrier | Rt frontal/parietal lobe | No | 1E+08 | Astrocytoma | High | 11 |
| 010 | 7 | 34.4 | M-N | American Bulldog | Rt temporal lobe | No | 1E+09 | Oligodendroglioma | High | 43 |
| 011 | 4 | 52.0 | M-N | Great Dane | Lt forebrain | No | 1E+09 | Oligodendroglioma | High | 219 |
| 012 | 11.5 | 11.4 | M-N | Boston Terrier | Lt frontal lobe | No | 1E+09 | Oligodendroglioma | Undetermined | 378* |
| 013 | 8 | 39.6 | F-S | Mixed breed | Rt temporal lobe | No | 1E+09 | Oligodendroglioma | High | 43 |
| 014 | 8 | 11.6 | M-N | Boston Terrier | Lt frontal lobe | No | 1E+09 | Oligodendroglioma | Low | 369* |
| 015 | 14.5 | 41.0 | M-N | Boxer | Rt temporal lobe | No | NA | Oligodendroglioma | Low | Died of pneumonia prior to inoculation |
| 016 | 10 | 24.1 | F-S | Border Collie | Rt forebrain | No | 1E+09 | Undefined with astrocytic features | Low | 362* |
| 017 | 11 | 8.47 | M-N | Boston Terrier | Rt temporal lobe | No | 1E+09 | Oligodendroglioma | Low | 28 |
| 018 | 9.5 | 11.6 | M-N | French Bulldog | Lt parietal lobe | No | 1E+09 | Oligodendroglioma | High | 70 |
| 019 | 9 | 5.0 | M-N | Yorkshire Terrier | Rt temporal lobe | No | 1E+09 | Glioblastoma | High | 55 |
| 020 | 5 | 26.0 | M-N | Mixed breed | Rt temporal lobe | No | 1E+09 | Oligodendroglioma | High | 28 |
| 021 | 5 | 28.6 | M-N | Golden Retriever | Rt occipital lobe | No | 1E+09 | Astrocytoma | High | 103* |
| 022 | 6.5 | 34 | M-N | Boxer | Lt temporal lobe | No | NA | Granulomatous meningoencephalitis | NA | Died of pneumonia prior to inoculation |
| 023 | 7 | 29.1 | F-S | Mixed breed | Rt temporal lobe | No | 1E+09 | Undetermined | Undetermined | 39* |
| 024 | 7.5 | 33.1 | M-I | Boxer | Lt frontal lobe | No | NA | Glioblastoma | High | Died of pneumonia prior to inoculation |
| 025 | 6.5 | 37.2 | M-I | Cane Corso | Lt frontal/parietal lobe | No | 1E+09 | Astrocytoma | High | 33* |
I = intact; N = neutered; NA = not applicable; S = spayed.
*
Canines still living.