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. Author manuscript; available in PMC: 2021 Aug 24.
Published in final edited form as: Neurosurg Focus. 2021 Feb;50(2):E5. doi: 10.3171/2020.11.FOCUS20844

TABLE 4.

Interim data on canine characteristics, viral dosing, tumor pathology, and survival after administration of M032

ID
No.
Age at
Treatment
(yrs)
Weight at
Treatment
(kg)
Sex-Neuter,
Spay, or
Intact
Breed Tumor
Location
Prior
Treatment
M032
Dose
(pfu)
Tumor
Pathology
Tumor
Grade
Posttreatment
Survival (days)
001 6 14.1 M-N English Bulldog Lt frontal/parietal lobe No 1E+06 Oligodendroglioma Low 108
002 10 24.1 M-N Boxer Rt frontal lobe No 1E+06 Oligodendroglioma High 372
003 7 23.0 M-N English Bulldog Lt parietal/occipital lobe No 1E+06 Oligodendroglioma High 232
004 9 7.03 M-N Yorkshire Terrier Rt frontal lobe Yes 1E+07 Astrocytoma Low 188
005 7 53.0 M-N Mixed breed Lt piriform lobe Yes 1E+07 Oligodendroglioma High 151
006 6 10.8 M-N Boston Terrier Rt forebrain No 1E+07 Astrocytoma Undetermined 415
007 7 12.7 M-N Mixed breed Rt rostral fossa No 1E+08 Oligodendroglioma Undetermined Left study to pursue alternate treatment
008 6 55.2 F-S German Shepherd Rt frontal lobe No 1E+08 Oligodendroglioma High 41
009 11 8.6 F-S Boston Terrier Rt frontal/parietal lobe No 1E+08 Astrocytoma High 11
010 7 34.4 M-N American Bulldog Rt temporal lobe No 1E+09 Oligodendroglioma High 43
011 4 52.0 M-N Great Dane Lt forebrain No 1E+09 Oligodendroglioma High 219
012 11.5 11.4 M-N Boston Terrier Lt frontal lobe No 1E+09 Oligodendroglioma Undetermined 378*
013 8 39.6 F-S Mixed breed Rt temporal lobe No 1E+09 Oligodendroglioma High 43
014 8 11.6 M-N Boston Terrier Lt frontal lobe No 1E+09 Oligodendroglioma Low 369*
015 14.5 41.0 M-N Boxer Rt temporal lobe No NA Oligodendroglioma Low Died of pneumonia prior to inoculation
016 10 24.1 F-S Border Collie Rt forebrain No 1E+09 Undefined with astrocytic features Low 362*
017 11 8.47 M-N Boston Terrier Rt temporal lobe No 1E+09 Oligodendroglioma Low 28
018 9.5 11.6 M-N French Bulldog Lt parietal lobe No 1E+09 Oligodendroglioma High 70
019 9 5.0 M-N Yorkshire Terrier Rt temporal lobe No 1E+09 Glioblastoma High 55
020 5 26.0 M-N Mixed breed Rt temporal lobe No 1E+09 Oligodendroglioma High 28
021 5 28.6 M-N Golden Retriever Rt occipital lobe No 1E+09 Astrocytoma High 103*
022 6.5 34 M-N Boxer Lt temporal lobe No NA Granulomatous meningoencephalitis NA Died of pneumonia prior to inoculation
023 7 29.1 F-S Mixed breed Rt temporal lobe No 1E+09 Undetermined Undetermined 39*
024 7.5 33.1 M-I Boxer Lt frontal lobe No NA Glioblastoma High Died of pneumonia prior to inoculation
025 6.5 37.2 M-I Cane Corso Lt frontal/parietal lobe No 1E+09 Astrocytoma High 33*

I = intact; N = neutered; NA = not applicable; S = spayed.

*

Canines still living.