. 2021 Aug 23;78(10):1–6. doi: 10.1001/jamaneurol.2021.2806

Table 2. Association of X Chromosome Genes Expression With Cognition and Neurofibrillary Tangle Burden in a Sex-Specific Manner^a.

Characteristic	X-linked gene	Women		Men
Characteristic	X-linked gene	β	P value	β	P value
Cognition	APLN	−0.0257	<.001^b	−0.0141	.45
	FOXO4	−0.0253	.002^b	−0.0166	.32
	WWC3	−0.0259	.002^b	−0.0039	.86
	MID1IP1	−0.0247	.002^b	−0.0144	.37
	MED12	−0.0242	.003^b	−0.0143	.37
	PPEF1	0.0230	.004^b	0.0157	.35
	EIF1AX	0.0221	.006^b	0.0112	.54
	GPRASP1	0.0214	.008^b	0.0124	.48
	GPRASP2	0.0221	.008^b	0.0131	.41
	NGFRAP1	0.0203	.01^b	0.0067	.75
	ZCCHC12	0.0205	.01^b	0.0070	.74
	FAM156B	0.0191	.02^b	0.0034	.90
	XK	0.0194	.02^b	0.0096	.61
	ACSL4	0.0194	.02^b	0.0033	.90
	VMA21	0.0187	.02^b	0.0206	.21
	RLIM	0.0190	.02^b	−0.0009	.98
	PHF16	−0.0187	.03^b	−0.0096	.64
	IRAK1	−0.0181	.03^b	−0.0100	.60
	GRIPAP1	0.0189	.03^b	0.0038	.88
	BEX2	0.0180	.03^b	0.0119	.51
	IL2RG	−0.0168	.03^b	−0.0105	.62
	ASMTL	0.0177	.03^b	0.0157	.36
	NAP1L2	0.0175	.03^b	0.0088	.66
	OTUD5	0.0181	.03^b	0.0083	.65
	RAB9A	−0.0175	.03^b	−0.0141	.41
	DYNLT3	0.0174	.03^b	0.0126	.49
	PNCK	0.0166	.045^b	0.0058	.80
	GRIA3	0.0173	.047^b	0.0098	.60
	POLA1	−0.0157	.049^b	−0.0137	.47
Neurofibrillary tangles	EMD	−0.0325	.57	−0.0982	.03^b
	UBL4A	0.0206	.75	0.0975	.03^b
	PHF16	0.0343	.57	0.0901	.03^b

^{^a}

Models for each sex include covariates for age at death and educational attainment.

^{^b}

Significant false discovery rate–adjusted P values for genome-wide correction are indicated.

Table 2. Association of X Chromosome Genes Expression With Cognition and Neurofibrillary Tangle Burden in a Sex-Specific Mannera.