KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
CD45	BioLegend	103116
CD3	Fisher	460032-80
CD4	BioLegend	100438
CD8	BioLegend	100712
NK1.1	BioLegend	108708
CD19	Miltenyi	130-105-171
CD44	BioLegend	103025
CD62L	BioLegend	104417
TIM3	BioLegend	119721
LAG3	BioLegend	125219
CXCR3	BioLegend	126531
CD8a	Thermofisher	46-0081-82
CD11C	BioLegend	117330
F4/80	Thermofisher	17-4801-80
CD206	BioLegend	141705
CD11b	BioLegend	101217
I-A/I-E	BioLegend	107622
Ly6G	BioLegend	127617
Ly-6C	BioLegend	128035
CD103	BD	564322
PD-L1	BD	740614
CD45	BD	564279
CD69	Invitrogen	11-0691-85
FOXP3	BioLegend	126404
CD25	Invitrogen	56-0251-80
MHC Class I	Invitrogen	25-5958-80
CD137	Invitrogen	46-1371-80
CD134	BD	740945
CD3e	BD	563024
CD8	BioLegend	100712
CD11b	BioLegend	101267
CD8-depleting antibody (YTS 169.4)	BioXcell (West Lebanon, NH)	BPO 117
Anti-OX-40 (OX-86)	BioXcell (West Lebanon, NH)	BE0031
Anti-4-1BB (LOB12.3)	BioXcell (West Lebanon, NH)	BPO169
Purified anti-mouse CD183 (CXCR3)	Biolegend	126502
Anti-CD3e	Biolegend	100302
Anti-CD28	Biolegend	102102
Anti-mouse CD16/32	Biolegend	156604
RB1	Cell signaling	9309S
Phospho- RB (S807/S811) rabbit antibody	Cell signaling	8516S
S6 Ribosomal protein rabbit antibody	Cell signaling	2217S
Phospho-S6 (S235/236) Ribosomal protein rabbit antibody	Cell signaling	2211S
Phospho-S6 (S240/244) ribosomal protein rabbit antibody	Cell signaling	5364T
Phospho-p70 S6 (T389) kinase rabbit antibody	Cell signaling	9234T
p70 S6 kinase rabbit antibody	Cell signaling	2708T
p21 Waf1/Cip1 rabbit antibody	Cell signaling	2947S
β-actin rabbit antibody	Cell signaling	4970S
β-tubulin rabbit antibody	Cell signaling	2146S
HSP90 rabbit antibody	Cell signaling	4874S
Bacterial and Virus Strains
NA
Biological Samples
NA
Chemicals, Peptides, and Recombinant Proteins
Dulbecco’s modified Eagle’s medium/F12	Gibco	11330032
GlutaMAX	Gibco	35050061
Gibco™ Penicillin-Streptomycin	Gibco	15-140-122
Fetal Bovine Serum	Gibco	16000036
Palbociclib	Pfizer	NA
Palbociclib	LC laboratories	P-7766
Rapamycin	Tocris	1292
N-acetylcysteine	Sigma	A9165
benzylserine	Sigma	13900
Bay876	Sigma	SML1774
BKM120	Sigma	10296
Maraviroc	Adooq	A10556
CellTracker Green CMFDA Dye	Invitrogen	C2925
Murine recombinant CCL5	Peprotech	25007
MitoTracker Green	Invitrogen	T7514
CellRox Deep Red	Invitrogen	C10422
LysoTracker Deep Red	Invitrogen	L12492
DAPI	Invitrogen	D1306
Hoechst 33342	Invitrogen	H1399
JC-1 Mitochondrial Membrane Potential Dye	Thermo Fisher	3168
Fixable Viability Dye eFluor™ 780	Invitrogen	65-0865-14
LIVE/DEAD™ Fixable Aqua Dead Cell Stain Kit	Thermofisher	L34957
Everolimus	LC Laboratories	E-4040
10X Tris/Glycine/SDS Buffer	Biorad	1610772
Tris Buffer Saline	Fisher Bioreagents	BP2471-1
Tween 20	Fisher Bioreagents	BP 337-500
Trans Blot Turbo RTA transfer kit	Biorad	170-4270
Bovine serum Albumin	Fisher Bioreagents	BP9706-100
Protein assay dye reagent concentrate	Biorad	5000006
Critical Commercial Assays
Reverse Phase Protein Array (RPPA)	Core Facility at MD Anderson Cancer Center (Houston, TX)	NA
RNA-easy mini kit	Qiagen	74104
iScript cDNA synthesis kit	BioRad	1708890
Quantiline ELISA HumanCXCL10/IP-10	R&D system	DIP100
Quantiline ELISA Human CCL5/RANTES	R%D system	DRN00B
Tumor tissue dissociation kit	Miltenyi Biotech	130-096-730
FXP3/ Transcription Factor Staining Buffer Set	Invitrogen	00-5523-00
SYBR-green master mix	BioRad	1725270
Senescence β-Galactosidase Staining Kit	Sigma	CS0030
Deposited Data
N/A
Experimental Models: Cell Lines
MCF7 Cell line	American Type Culture Collection	ATCC® HTB22™
Cal120 cell line	Carlos L. Arteaga Vanderbilt-Ingram Cancer Center.	NA
MDA-MB-453 cell line	Carlos L. Arteaga Vanderbilt-Ingram Cancer Center.	NA
MDA-MB-468 cell line	Carlos L. Arteaga Vanderbilt-Ingram Cancer Center.	NA
HCC70 cell line	Carlos L. Arteaga Vanderbilt-Ingram Cancer Center.	NA
BT20 cell line	Carlos L. Arteaga Vanderbilt-Ingram Cancer Center.	NA
PYMT cell line	Philip Owens (VA Eastern Colorado Health Care System, Denver, CO)	NA
PYMT-OVA cell line	David DeNardo (Washington University St. Louis, St. Louis MO)	NA
Experimental Models: Organisms/Strains
C57BL/6 mice	The Jackson Laboratory	000664
C57BL/6 mice	Charles River/NCI	Strain code :027
OT-1 mice	Marc Boothby, Richard O’Neil (Vanderbilt University, Nashville, TN)	NA
OT-1 mice	The Jackson Laboratory	003831
FVB-PYMT transgenic mice	Harold Moses (Vanderbilt University, Nashville, TN)	NA
Oligonucleotides
Primer: h CXCL10 F GTGGCATTCAAGGAGTACCTC	Sigma	NA
Primer: h CXCL10 R TGATGGCCTTCGATTCTGGATT	Sigma	NA
Primer: h CXCL9 F CCAGTAGTGAGAAAGGGTCGC	Sigma	NA
Primer: h CXCL9 R AGGGCTTGGGGCAAATTGTT	Sigma	NA
Primer: m CXCL9 F GGAGTTCGAGGAACCCTA	Sigma	NA
Primer: m CXCL9 R GGGATTTGTAGTAGTGGATCGTGC	Sigma	NA
Primer: m CCL5 F GCTGCTTTGCCTACCTCTCC	Sigma	NA
Primer: m CCL5 R TCGAGTGACAAACACGACTGC	Sigma	NA
Primer: h CCL5 F CCAGCAGTCGTCTTTGTCAC	Sigma	NA
Primer: h CCL5 R CTCTGGGTTGGCACACACTT	Sigma	NA
Recombinant DNA
NA
Software and Algorithms
ImageJ	NIH Image	https://imagej.nih.gov/ij/index.html
Graphpad’s Prism 7.03 software	GraphPad	https://www.graphpad.com/
R (version3.3.0.)	Bioconductor	https://www.bioconductor.org/packages/devel/bioc/vignettes/limma/inst/doc/usersguide.pdf
Timer version 2.0	Li et al, 2020	http://timer.cistrome.org/
Morpheus	Broad Institute	https://software.broadinstitute.org/morpheus/
cBioPortal for Cancer Genomics version 3.6.3	Cerami et al, 2012	https://www.cbioportal.org/
Other
N/A