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. 2021 Aug 10;12:716305. doi: 10.3389/fimmu.2021.716305

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Copyright © 2021 Knudsen, Björnsson, Bassi, Walker, Kok, Cristinoi, Jensen and Barfod

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Isobologram analysis of GIA effects when combining anti-PfCyRPA mAbs. The isobolograms show the effect of combining anti-PfCyRPA mAbs using fixed-ratio mixtures (5:0, 4:1, 3:2, 2:3, 1:4 and 0:5) against P. falciparum 3D7. The x and y axes show the FIC₅₀ values of the two mAbs taking part of the combination. The grey dashed line indicates the expected results following the definition of Loewe additivity. The purple line links the observed values of each ratio of the mAb combination that induces 50% GIA. The points below the additivity line indicates synergy, while points above indicate antagonism. The following mAb combinations were investigated: CyP1.9:CyP2.38, CyP1.9:CyP2.39 and CyP2.38:CyP2.39.