TABLE 1.
Demographic and clinical characteristics of the 86 patients with cryptococcosis.
| Variables | C. neoformans var. grubii (n = 75) | Cryptococcus gattii (n = 11) |
| Age, year, average | 46.58 | 38.09 |
| Gender, male | 51 | 8 |
| HIV (+), n | 14 | – |
| Underlying diseases | ||
| None, n | 51 | 4 |
| Diabetes mellitus, n | 7 | – |
| HBV, n | 13 | 5 |
| HCV, n | 1 | 2 |
| Liver diseasesa, n | 4 | 1 |
| Liver cancer, n | 3 | – |
| Corticosteroids administration, n | 1 | – |
| Autoimmune diseasesb, n | 4 | 1 |
| Clinical diagnosis | ||
| Cryptococcal meningitis | 47 | 10 |
| Pulmonary cryptococcosis | 8 | 1 |
| Disseminated cryptococcosis | 20 | – |
| Clinical symptoms | ||
| Neurological abnormalitiesc, n | 31 | 1 |
| Headache, n | 61 | 9 |
| Fever, n | 51 | 9 |
| Cough, n | 13 | 2 |
| Vomiting, n | 39 | 6 |
| Abnormal vision, n | 2 | 2 |
| Skin lesions, n | 1 | – |
| Treatment outcome | ||
| Survived, n | 47 | 10 |
| Died, n | 27 | 1 |
| Unknown, n | 1 | – |
| Specimen source | (n = 92) | (n = 11) |
| CSF, n | 81 | 10 |
| Lung tissue, n | 6 | 1 |
| BALF, n | 3 | – |
| Skin tissue, n | 2 | – |
n, number; HBV, hepatitis B virus; HCV, hepatitis C virus; CSF, cerebrospinal fluid; BALF, bronchoalveolar lavage fluid.
aLiver cirrhosis, fatty liver.
bSystemic lupus erythematous, rheumatoid arthritis.
cConvulsion, altered consciousness, epilepsy.