Table 1. Mean ± SE K₁ and V_T Values of All Selected Brain Regions in All Experimental Groups, Percentages of Change Relative to the Control Group, and p-Values.

		K1 (mL/(mL min))			VT (mL/mL)
region	group	mean ± SE	changes relative to control (%)	p-value	mean ± SE	changes relative to control (%)	p-value
amygdala	control	0.27 ± 0.02			7.38 ± 0.47
	4.5 mg/kg	0.27 ± 0.02	–0.94	0.92	6.94 ± 0.47	–6.03	0.50
	6 mg/kg	0.19 ± 0.02	–30.62	0.00	5.41 ± 0.51	–26.81	0.00
basal ganglia	control	0.27 ± 0.02			6.23 ± 0.33
	4.5 mg/kg	0.26 ± 0.02	–4.63	0.62	5.89 ± 0.33	–5.53	0.46
	6 mg/kg	0.19 ± 0.02	–30.43	0.00	4.6 ± 0.36	–26.19	0.00
brainstem	control	0.41 ± 0.03			8.66 ± 0.43
	4.5 mg/kg	0.37 ± 0.03	–8.80	0.31	7.88 ± 0.43	–9.02	0.20
	6 mg/kg	0.29 ± 0.03	–29.33	0.00	6.1 ± 0.48	–29.63	0.00
cerebellum	control	0.38 ± 0.02			8.7 ± 0.49
	4.5 mg/kg	0.36 ± 0.02	–4.77	0.58	8.18 ± 0.49	–6.01	0.45
	6 mg/kg	0.26 ± 0.03	–30.60	0.00	6.41 ± 0.54	–26.37	0.00
corpus callosum	control	0.26 ± 0.02			7.25 ± 0.34
	4.5 mg/kg	0.23 ± 0.02	–8.00	0.43	7.04 ± 0.34	–2.80	0.68
	6 mg/kg	0.17 ± 0.02	–34.47	0.00	5.65 ± 0.37	–22.08	0.00
cortex	control	0.27 ± 0.02			8.57 ± 0.41
	4.5 mg/kg	0.24 ± 0.02	–9.65	0.29	8.07 ± 0.41	–5.89	0.38
	6 mg/kg	0.17 ± 0.02	–36.39	0.00	6.76 ± 0.45	–21.19	0.00
hippocampus	control	0.27 ± 0.02			6.8 ± 0.35
	4.5 mg/kg	0.26 ± 0.02	–1.33	0.90	6.5 ± 0.35	–4.48	0.54
	6 mg/kg	0.18 ± 0.02	–33.77	0.00	5.24 ± 0.38	–22.94	0.00
hypothalamus	control	0.35 ± 0.03			7.57 ± 0.37
	4.5 mg/kg	0.33 ± 0.03	–3.30	0.75	7.27 ± 0.37	–3.96	0.57
	6 mg/kg	0.24 ± 0.03	–30.33	0.00	6.08 ± 0.41	–19.61	0.01
medial geniculate	control	0.32 ± 0.03			6.06 ± 0.29
	4.5 mg/kg	0.3 ± 0.03	–5.13	0.72	5.85 ± 0.29	–3.59	0.59
	6 mg/kg	0.2 ± 0.04	–35.96	0.02	4.65 ± 0.32	–23.34	0.00
mesencephalic region	control	0.35 ± 0.02			7.14 ± 0.33
	4.5 mg/kg	0.34 ± 0.02	–1.86	0.83	6.65 ± 0.33	–6.75	0.31
	6 mg/kg	0.26 ± 0.02	–26.91	0.00	5.49 ± 0.37	–23.00	0.00
midbrain	control	0.35 ± 0.02			7.07 ± 0.34
	4.5 mg/kg	0.33 ± 0.02	–5.43	0.52	6.92 ± 0.34	–2.13	0.75
	6 mg/kg	0.26 ± 0.02	–25.27	0.00	5.58 ± 0.37	–21.06	0.00
septum	control	0.27 ± 0.02			6.37 ± 0.35
	4.5 mg/kg	0.26 ± 0.02	–5.95	0.60	5.91 ± 0.35	–7.23	0.35
	6 mg/kg	0.17 ± 0.02	–38.90	0.00	4.89 ± 0.38	–23.28	0.00
striatum	control	0.26 ± 0.02			6.36 ± 0.32
	4.5 mg/kg	0.24 ± 0.02	–9.46	0.33	6.05 ± 0.32	–5.00	0.48
	6 mg/kg	0.17 ± 0.02	–35.30	0.00	4.95 ± 0.35	–22.18	0.00
superior colliculus	control	0.39 ± 0.03			6.98 ± 0.33
	4.5 mg/kg	0.36 ± 0.03	–9.66	0.30	6.34 ± 0.33	–9.21	0.17
	6 mg/kg	0.25 ± 0.03	–37.67	0.00	5.13 ± 0.36	–26.42	0.00
thalamus	control	0.3 ± 0.02			6.19 ± 0.31
	4.5 mg/kg	0.29 ± 0.02	–3.23	0.76	5.89 ± 0.31	–4.82	0.49
	6 mg/kg	0.2 ± 0.03	–33.61	0.00	4.54 ± 0.34	–26.70	0.00
whole-brain	control	0.3 ± 0.02			7.82 ± 0.38
	4.5 mg/kg	0.28 ± 0.02	–7.18	0.42	7.35 ± 0.38	–5.99	0.38
	6 mg/kg	0.2 ± 0.02	–33.68	0.00	5.92 ± 0.41	–24.29	0.00