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. Author manuscript; available in PMC: 2021 Aug 24.
Published in final edited form as: Nat Genet. 2020 Aug 17;52(9):908–918. doi: 10.1038/s41588-020-0642-1

Figure 6 |. Luminal-C cells in the normal human prostate.

Figure 6 |

a, Visualization of the clustering of 11,374 single human prostate cells based on the expression of known marker genes by t-SNE. h-Luminal-A/B, type A/B luminal cell; h-Luminal-C, type C luminal cell; h-Basal, basal cell; h-Stromal, stromal cell; h-Macro, macrophage; h-Endo, endothelial cell; h-Lymph, lymphocyte. b, T-SNE maps show the expression levels of h-Luminal-C marker genes (CK4, PSCA, TACSTD2 and PIGR) across 7 clusters (n = 11,374 cells). c, Immunofluorescence staining of TACSTD2, TP63 (upper panel) and CK8 (lower panel) showed that Luminal-C cells reside in normal human prostate invagination tips (red arrows). d, Immunofluorescence staining of CK4 (upper panel), PIGR (middle panel), PSCA (lower panel) and TP63 showed that Luminal-C cells reside in normal human prostate invagination tips (red arrows). These experiments were administered three times with similar results (c,d). Scale bars, 50 μm (c-d)