TABLE 4.
Main pharmacokinetic parameters of Indo5 following intravenous or oral administration.
| Parameters | Intravenous administration (IV) 1 mg/kg | Oral administration (p.o.) 100 mg/kg |
|---|---|---|
| t1/2 (h) | 0.63 ± 0.11 | 1.25 ± 0.24 |
| Tmax (h) | 0.0167 | 2.0 ± 0.48 |
| Cmax (ng/ml) | 1,565.3 ± 286.2 | 54.7 ± 10.4 |
| AUC0-t (h*ng/ml) | 158.6 ± 27.9 | 251.5 ± 43.5 |
| AUC0-∞ (h*ng/ml) | 163.4 ± 28.3 | 255.7 ± 44.9 |
| Vd (ml/kg) | 5,588 ± 9,433.8 | 706349 ± 106941.2 |
| CL (ml/h/kg) | 6,121.6 ± 1,124.8 | 391056.4 ± 77,945.8 |
| MRT0-t (h) | 0.18 ± 0.04 | 2.87 ± 0.61 |
| MRT0-∞ (h) | 0.26 ± 0.06 | 2.99 ± 0.63 |