FIGURE 3.

Voxel‐wise effect of diagnosis and history of head injury on tau deposition. (A) A significant main effect of history of head injury (HI) with or without a loss of consciousness (LOC) was observed, with significant clusters indicating greater [¹⁸F]flortaucipir SUVR in the parietal and frontal lobes. (B) In addition, an interaction between diagnosis and history of HI was observed, with significant clusters in the medial and lateral parietal lobes. (C) A similar but more extensive pattern of the frontal and parietal lobes shows a significant main effect of TBI with LOC. (D) An interaction between diagnosis and history of HI with LOC was also observed, with significant clusters in the frontal and parietal lobes. Significant effects of diagnosis were also observed (data not shown). All results shown at a cluster‐wise threshold of P < 0.05 (family‐wise error correction for multiple comparisons) and covaried for age, sex, global cortical amyloid, and cohort. Note: For (A) and (B), participants include 412 CN without history of HI, 38 CN with history of HI, 277 impaired without history of HI, 25 impaired with history of head injury; for (C) and (D), participants include 432 CN without history of HI with LOC, 18 CN with history of HI with LOC, 289 impaired without history of HI with LOC, 13 impaired with history of head injury with LOC. Abbreviations: CN, cognitively normal; HI, head injury; L, left; LOC, loss of consciousness; R, right; TBI, traumatic brain injury