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. 2021 Aug 10;12:719312. doi: 10.3389/fgene.2021.719312

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Copyright © 2021 Li, Wang, Qian, Wu, Zhang, Hu and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Function of exosomes derived from high-glucose (HG)-induced human retinal vascular endothelial cells (HRVECs) on angiogenesis in vitro. (A) Endothelial cells phagocytosed exosomes labeled by PKH26. (B,C) Exosomes derived from HG-induced HRVECs can enhance the migration (B) and tube formation ability (C) of endothelial cells (ECs) in comparison to negative control (NG) exosomes. Representative images of wound healing and tube formation are shown along with quantitative data (n = 3). Scale bar, 100 μm. ***P < 0.0002, ****P < 0.0001.