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Function of circFndc3b in angiogenesis in vitro. (A) Small interfering RNA 2 had the greatest interference efficiency. (B,C) circFndc3b knockdown can reduce the migration (B) and tube formation ability (C) of endothelial cells (ECs) in comparison to the negative control. Representative images of wound healing and tube formation are shown along with quantitative data (n = 3). Scale bar, 100 μm. *P < 0.0332, **P < 0.0021, ***P < 0.0002, ****P < 0.0001.
