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. 2021 Aug 23;12:474. doi: 10.1186/s13287-021-02526-z

Table 1.

Surface marker phenotype and in vitro/in vivo differentiation of human endometrial stem cells

Cell type Positive marker Negative marker In vitro and in vivo differentiation References
MenSCs CD73, CD90, CD105, CD13, CD44, CD29, CD9, CD44, CD41a, CD59 CD19, CD34, CD45, CD117, CD130, HLA-DR Adipocytes, osteocytes, cardiomyocytes, neurocytes, respiratory epithelial cells, endothelial cells, myocytes, hepatic cells, pancreatic cells, and germ-like cell [42, 43]
Endometrial SPs of epithelial origin CD9, CD90, CD105, CD73, CD45, CD34, CD31, CD133, stro-1 CD9, CD13 Adipocytes, osteocytes [96, 97]
Endometrial SPs from the stromal compartment Vimentin, CD90, CD73, CD45, CD34, CD31, CD133, stro-1 CD9, CD13, CD105, ERα, PR Adipocytes, osteocytes [97]
SUSD2+ eMSCs CD29, CD44, CD73, CD90, CD105, CD117, CD140b, CD146, and STRO-1, NTPDase2 CD31, CD45 Adipocytes, osteocytes, chondrocytes, myocytes, endothelial cells [12]
CD140b+CD146+ eMSCs CD29, CD44, CD73, CD90, CD105, CD140b, CD146 CD31, CD34, CD45 Osteocytes, myocytes, adipocytes, chondrocytes, fibroblasts and smooth muscle cell [12, 14, 15]
CD146+ cells CD10, CD13, CD44, CD73, CD90, and CD105 CD31, CD34, CD45, CD56, CD144, CD9 Adipocytes, osteoblasts, and neuron-like cells, glial-like cells [19, 21]
Epithelial stem/progenitor cells N-cadherin, SSEA-1, Axin 2 Entire complement of glandular lineages, endometrial organoids [104, 107, 150]

MenSCs menstrual stem cells, SPs side population cells, eMSCs endometrial mesenchymal stem cells