Fig. 4.

rhIL-37 increased the ratio of Th1/Th2 via inducing EMs-DCs to mature. The control-DCs and EMs-DCs were co-cultured with CD4⁺T cells. At the same time, the DCs were treated with or without rhIL-37 and LPS. (A-C) The percentages of Th1 and Th2 cells, and the ratio of Th1/Th2 cells in CD4⁺T cells was analyzed by flow cytometry; (D-G) the expression levels of IFN-γ mRNA, TNF-α mRNA, IL-4 mRNA, and IL-13 mRNA in CD4⁺T cells were measured by qRT-PCR. N = 3. **P < 0.01 compared with CD4⁺T, ^##P < 0.01 CD4⁺T + Control-DC, and ^&&P < compared with CD4⁺T + EMs-DCs