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The presentation model for R-2-HG in tumorigenesis. R-2-HG produced by mIDH1/2 inhibits the α-KG dependent dioxygenases include DNA demethylase, histone demethylase, and PHD, leading to the hypermethylation of DNA and histone, and the increase of HIF-1α, respectively. These epigenetic alterations result in the blockade of cell differentiation and promote the initial engraftment and proliferation of tumor cells
