Table 1.
Study population characteristics by P. falciparum infection at enrolment
| Variable |
Total (N=302) |
Uninfected at enrolment (N=199) |
Infected at enrolment (N=103) |
|---|---|---|---|
| Enrolment demographics | |||
| Age | 24 (21–28) | 24 (21–30) | 23 (20–27) |
| Gestational age (weeks) | 26 (22–28) | 26 (22–28) | 25 (22–29) |
| Gravidity | |||
| Primigravid | 115/302 (38%) | 66/199 (33%) | 49/103 (48%) |
| Multigravid | 187/302 (62%) | 133/199 (67%) | 54/103 (52%) |
| Middle upper arm circumference | 22 (21–23) | 23 (21–24) | 22 (22–23) |
| Smokes | 60/301 (20%) | 40/199 (20%) | 20/2102 (20%) |
| Infections at enrolment | |||
| Peripheral P. falciparuma | 103/302 (34%) | 0/199 (0%) | 103/103 (100%) |
| Infections at delivery | |||
| Peripheral P. falciparuma | 32/288 (11%) | 22 /190 (12%) | 11/98 (11%) |
| Placental histologyb | |||
| No infection | 81/233 (35%) | 64/154 (41) | 17/79 (21%) |
| Acute infection | 90/233 (39%) | 64/154 (39%) | 30/79 (38%) |
| Chronic infection | 42/233 (18%) | 21/154 (14%) | 21/79 (27%) |
| Past infection | 20/233 (8%) | 9/154 (6%) | 11/79 (14%) |
| Hemoglobin at delivery | |||
| Hemoglobin (g/dl) | 9.4 (8.2–10.3) | 9.4 (8.2–10.5) | 9.2 (8.2–10.2) |
| Severe anemia (<8g/dl) | 68/285 (24%) | 45/188 (24%) | 23/97 (24%) |
| Residence | |||
| Town | 7/299 (2%) | 7/197 (4%) | 0/102 (0%) |
| Village | 292/299 (98%) | 190/197 (96%) | 102/102 (100%) |
| Maternal Genetics | |||
| SAO | |||
| Normal | 261/302 (86%) | 176/199 (88%) | 85/103 (83%) |
| SAO | 41/302 (14%) | 23/199 (12%) | 18/103 (17%) |
| α+thalassaemia | |||
| Normal α globin | 59/302 (20%) | 40/199 (20%) | 19/103 (19%) |
| Heterozygous | 112/302 (43%) | 72/199 (36%) | 40/103 (39%) |
| Homozygous | 131/302 (37%) | 87/199 (44%) | 44/103 (43%) |
Data are presented as median (25th percentile—75th percentile) and n/total (%) for categorical valuables
aParasite positive by light microscopy, confirmed by PCR. bPlacental infection confirmed by histology. Missing data for variables of; age and gestational age (n=13), smoker (n=1), middle upper arm circumference (n=12), peripheral parasitaemia at delivery (n=14), placental histology (n=69), Hb at delivery (n=17), and location of residence (n=3)