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. 2021 Aug 23;14:40. doi: 10.1186/s13072-021-00416-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — ecDNA and linear DNA have the different chromatin accessibility pattern. A Density distribution of the methylation ratio in ecDNA and linear DNA. B Average chromatin status around ecDNA neighboring regions is illustrated. The junction site and its right neighboring regions demonstrate the more open chromatin. C Average methylations of gene regions on ecDNA and linear DNA (from TSS to TES). The genes were classified into two groups: (I) the genes on linear DNA have more open chromatin structure than ecDNA carried genes (above centerline); (II) the ecDNA carried genes have more open chromatin structure than the genes on linear DNA (below centerline). D Average CCDA-seq profile around transcription start site on ecDNAs and linear DNA. E Average CCDA-seq profile around the transcription end site in the ecDNA and linear DNAs (aggregated over 50-bp windows sliding every 5 bp; the sequencing depth was normalized for ecDNA and linear DNA; see Method for details)