Fig. 5.

The level and influx of taurine is elevated in ALS. a The immunoreactivity of taurine was increased in motor neurons of G93A mice. Scale bars030 μm (left) and 15 μm (right). b In vivo taurine levels within WT and G93A mice were measured by HPLC. **p<0.005, significantly different. c Time course of [³H] taurine uptake by NSC-34 cell lines (NSC-34, NSC-34/hSOD1^wt, and NSC-34/hSOD1^G93A). [³H] taurine uptake was performed at 37 °C. Each point. represents the mean±SEM (n04). The error bar is smaller than the size of the symbol in some cases. *p<0.05, significantly different. d Effect of taurine and β-alanine on the uptake of [³H] taurine by NSC-34 cell lines. Taurine uptake was measured after 5 min incubation with [³H] taurine. Each value represents the mean±SEM (n=4). **p<0.001, significantly different