Fig. 6.

Inhibition of taurine uptake by siRNA and β-alanine exacerbates cellular stress-induced motor neuronal cell death. a Knockdown of TauT with siRNA reduced TauT levels compared to siRNA control. b Knockdown of HSF1 with siRNA reduced HSF1 levels compared to siRNA control. c, d Cells were exposed to H₂O₂, NaAsO₂, and Tg. Knockdown of TauT and HSF1 exacerbated cellular stress-induced motor neuronal cell death. The data represent the mean±SEM of three separate experiments. e, f Treatment with taurine prevented the motor neuronal cell death under oxidative stress. g The induction of TauT by HSF1 may play a protective response to compensate oxidative stress in motor neurons under the ALS condition. *p<0.05, **p<0.005, significantly different