. 2020 Jul;26(25):3015–3025. doi: 10.2174/1381612826666200515134450

Table 2.

Included studies characteristics.

Publication Data				Demography							Care Product	Main Content	Investigated Parameters
First Author	Year of Publication	Design	Country	Population	Age (years)			Sex (Female/ Male)	N⁰ of Patients	N⁰ of Patients/ Groups
First Author	Year of Publication	Design	Country	Population	Mean	SD	Range	Sex (Female/ Male)	N⁰ of Patients	N⁰ of Patients/ Groups
Pham	2018	RCT, double-blind, crossover	Vietnam	healthy students with malodour	-	-	19-23	19/20	39	17	TheraBreath	0.1% chlorine dioxide	SL PI, LS GI, mWtci, T.f., F.n., P.g., T.d.
Pham	2018	RCT, double-blind, crossover	Vietnam	healthy students with malodour	-	-	19-23	19/20	39	22	placebo	0.9% sodium chloride	SL PI, LS GI, mWtci, T.f., F.n., P.g., T.d.
Siddeshappa	2018	RCT, double-blind,	India	mild to moderate gingivitis	-	-	20-50	16/24	40	20	HiOra	Herbal mouthwash	SL PI, LS GI, SBI, S.m., T.f., F.n.
Siddeshappa	2018	RCT, double-blind,	India	mild to moderate gingivitis	-	-	20-50	16/24	40	20	Freshclore	chlorine dioxide	SL PI, LS GI, SBI, S.m., T.f., F.n.
Yeturu	2016	RCT, single-blind, parallel	India	undergoing fix orthodontic treatment (mild to moderate gingivitis)	21,53	3,41	-	18/12	85	30	-	aloe vera	SL PI, LS GI,
					21,72	4,67	-	11/14		25	-	chlorhexidine
					21,7	3,01	-	16/14		30	Freshclore	chlorine dioxide
Aung	2015	RCT, single-blind, parallel	Japan	healthy	19,8	2,9	-	0/30	30	15	Fresh	chlorine dioxide	SL PI, SBI, mWtci,
Aung	2015	RCT, single-blind, parallel	Japan	healthy	19,8	2,9	-	0/30	30	15	Fresh	chlorine dioxide	SL PI, SBI, mWtci,	Shinada	2010	RCT, double-blind, crossover	Japan	healthy	22,9	6,2	19-38	0/15	15	8	Clo2 Fresh	0.1% chlorine dioxide	SL PI, LS GI, mWtci, T.f., F.n., P.g., T.d.
7	-	placebo												Shinada	2010	RCT, double-blind, crossover	Japan	healthy	22,9	6,2	19-38	0/15	15				SL PI, LS GI, mWtci, T.f., F.n., P.g., T.d.

RCT: randomised clinical trials; SL PI: Silness-Löe Plaque index; LS GI: Löe-Silness Gingival index, SBI: sulcular bleeding index; mWtci: modified Winkel tongue coating index; T.f.: Tannerella forsythia, F.n.: Fusobacterium nucleatum; P.g.: Prphyromonas gingivalis, T.d.: Treponema denticola; S.m.: Streptococcus mutans; SD: standard deviation.