. 2021 Aug 10;8:681668. doi: 10.3389/fmed.2021.681668

Table 3.

Clinical characteristics of patients with histopathological concordance or histopathological discordance.

Clinical diagnosis of melanocytic nevi
Characteristic			Histopathological discordance
		Overall histopathological concordance (N, %)	Overall histopathological discordance (N, %)	P-value^a	Seborrheic keratosis (N, %)	P-value^a	Basal cell carcinoma (N, %)	P-value^a	Melanoma (N, %)	P-value^a	Bowen's disease (N, %)	P-value^a	Squamous cell carcinoma (N, %)	P-value^a	Keratoacanthoma (N, %)	P-value^a
Number	4,561	3,745	816		470		64		24		16		4		2
		82.11%	17.89%		10.30%		1.40%		0.53%		0.35%		0.09%		0.04%
Sex				<0.001		<0.001		<0.001		0.077		<0.001		0.721		1.000
Male	1,459	1,099	360		201		37		11		13		2		1
	31.99%	29.35%	44.12%		42.77%		57.81%		45.83%		81.25%		50.00%		50.00%
Female	3,102	2,646	456		269		27		13		3		2		1
	68.01%	70.65%	55.88%		57.23%		42.19%		54.17%		18.75%		50.00%		50.00%
Age				<0.001		<0.001		<0.001		<0.001		<0.001		<0.001		0.007
Mean	31	27	45		48		55		50		43		49		63
Range	2–86	2–80	2–86		3–86		21–80		17–73		25–69		34–64		50–76
<60	4,346	3,689	657		376		39		14		12		2		1
	95.29%	98.50%	80.51%		80.00%		60.94%		58.33%		75.00%		50.00%		50.00%
≥60	215	56	159		94		25		10		4		2		1
	4.71%	1.50%	19.49%		20.00%		39.06%		41.67%		25.00%		50.00%		50.00%
Location				<0.001		<0.001		0.001		<0.001		<0.001		0.723		1.000
Head and neck	3,021	2,628	393		218		59		1		1		4		2
	66.24%	70.17%	48.16%		46.38%		92.19%		4.17%		6.25%		100.00%		100.00%
Trunk and limbs	1,081	749	332		228		3		6		3		0		0
	23.70%	20.00%	40.69%		48.51%		4.69%		25.00%		18.75%		0.00%		0.00%
Perineum and buttocks	141	83	58		18		2		2		10		0		0
	3.09%	2.22%	7.11%		3.83%		3.13%		8.33%		62.50%		0.00%		0.00%
Hands and feet	318	285	33		6		0		15		2		0		0
	6.97%	7.61%	4.04%		1.28%		0.00%		62.50%		12.50%		0.00%		0.00%
Reason for removal				<0.001		<0.001		<0.001		<0.001		0.018		0.094		0.261
Atypical clinical features	2152	1566	586		328		54		16		13		4		2
	47.18%	41.82%	71.81%		69.79%		84.38%		66.67%		81.25%		100.00%		100.00%
Changes in skin lesions	30	18	12		3		4		4		0		0		0
	0.66%	0.48%	1.47%		0.64%		6.25%		16.67%		0.00%		0.00%		0.00%
Cosmetic requirements	2225	2015	210		139		6		1		3		0		0
	48.78%	53.81%	25.74%		29.57%		9.38%		4.17%		18.75%		0.00%		0.00%
Repeated stimulation	154	146	8		0		0		3		0		0		0
	3.38%	3.90%	0.98%		0.00%		0.00%		12.50%		0.00%		0.00%		0.00%

Demographic comparison was made between the overall histopathological concordance group and histopathological discordance group.