TABLE 1.
Renal excretory responses to chronic HS (4% NaCl in diet) intake + AngII (25 ng/min) treatment for 4 weeks
| Mice strains | WI (ml/24 h) | V (ml/24 h) | UNaV (mM/24 h) | UKV (mM/24 h) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Basal | 2 week | 4 week | Basal | 2 week | 4 week | Basal | 2 week | 4 week | Basal | 2 week | 4 week | |
| WT (n = 7) | 1.4 ± 0.3 | 7.8 ± 1.6* | 11.1 ± 2.1* | 0.9 ± 0.1 | 5.5 ± 1.0* | 6.9 ± 0.9* | 118 ± 13 | 847 ± 118* | 883 ± 121* | 262 ± 32 | 251 ± 24 | 287 ± 12 |
| TNFR1KO (n = 7) | 2.8 ± 0.2 | 4.9 ± 1.5* | 13.8 ± 1.9* | 0.9 ± 0.2 | 3.8 ± 0.9* | 7.9 ± 0.8* | 96 ± 14 | 706 ± 133* | 942 ± 86* | 248 ± 44 | 234 ± 32 | 230 ± 13 |
| TNFR2KO (n = 6) | 2.1 ± 0.3 | 4.6 ± 1.3* | 11.4 ± 1.0* | 0.9 ± 0.1 | 3.3 ± 1.1* | 5.3 ± 0.8* | 104 ± 13 | 681 ± 116* | 732 ± 169* | 235 ± 32 | 218 ± 39 | 235 ± 32 |
The mean values of water intake (WI), urine output (V), sodium (UNaV), and potassium (UKV) excretion for 24 h metabolic cage collection samples during chronic HS (4% NaCl in diet) intake + AngII (25 ng/min) treatment for 4 weeks in different groups of mice. *p < 0.05 versus Basal values. Although the administration of ANGII and HS intake increased WI, V, and UNaV (but not UKV) in all three groups of mice, no significant differences were observed among groups in these increases in the urinary parameters.