Figure 4.

IP-10 does not promote resting memory CD4⁺ T cell activation. (A, B) Effect of IP-10 on the expression of the resting memory CD4⁺ T cell activation markers HLA-DR, CD69, and CD25 (A) and on the activation of resting memory CD4⁺ T cells by CD3/CD28 (B) at 6, 12, 24, and 48 h and 5 days post-treatment; representative flow cytometry plots from 3 participants and quantitative analyses are shown. The time point for HLA-DR, CD69, and CD25 of the representative flow cytometry plots are 5 days, 6 h and 24 h, respectively. The nonparametric Wilcoxon matched-pairs test was used for intergroup comparisons.