Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 10;12:656663. doi: 10.3389/fimmu.2021.656663

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Wang, Yin, Ma, Ge, Lang, Sun, He, Fu, Sun, Yu, Zhang, Cui, Han, Xu, Ding, Chu, Shang, Wu and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Model of IP-10-induced enhancement of latent HIV infection and reservoir establishment in resting memory CD4⁺ T cells. A signaling pathway common to HIV (gray solid line) and IP-10 (black solid line) induces actin activation. IP-10 binds to CXCR3 expressed on the surface of resting memory CD4⁺ T cells; Rac stimulates p21-activated kinase (PAK), which activates LIMK, leading to cofilin phosphorylation and actin polymerization. Another reported signaling pathway for latent HIV infection of resting CD4⁺ T cells (dotted line) involves HIV binding to CXCR4; the signal is transferred to CDC42, which activates Wiskott-Aldrich Syndrome family protein (WASP) and actin-nucleating protein (Arp2/3) to promote actin assembly.