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. 2021 Aug 4;22(4):1123. doi: 10.3892/etm.2021.10557

Figure 3.

Figure 3

Combination treatment with AST IV and PNS alleviates cerebral cortical cell injury in rats. H&E staining analysis of pathological changes in the cerebral cortices of rats in the. Black arrows indicate damaged cells. (A) sham, (B) model, (C) AST IV, (D) PNS and (E) combination groups (n=8 rats/group). (F) Damaged cell ratio. The groups are as follows: i) Sham, rats with sham operation; ii) model, rats with MCAO; iii) AST IV, rats with MCAO + 28 mg/kg AST IV; iv) PNS, rats with MCAO + 80 mg/kg PNS; and v) combination, rats with MCAO + 28 mg/kg AST IV + 80 mg/kg PNS. **P<0.01 vs. Sham; ##P<0.01 vs. Model; ΔΔP<0.01 vs. AST IV or PNS. AST IV, astragaloside IV; MCAO, middle cerebral artery occlusion; PNS, Panax notoginseng saponins.