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. 2021 Aug 4;22(4):1120. doi: 10.3892/etm.2021.10554

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of chemokine receptor antagonists on the migration and invasion of RA-FLS induced by PEVs. (A) Wound healing (a) and Transwell (b) assays were performed on RA-FLS treated with or without PEVs with different concentrations of BX471. (B) Wound healing (a), Transwell migration (b) and invasion assays (c) were performed on RA-FLS treated with or without PEVs with different concentrations of SB225002. (C) Wound healing (a) and (b) Transwell assays were performed on RA-FLS treated with or without PEVs with different concentrations of AMG487. Original magnification, x100. Wound healing scale bar, 800 µm; Transwell assay scale bar, 400 µm. Data are presented as the mean ± SD (n=3). ^*P<0.05 vs. the control group; ^#P<0.05 vs. 50 µg/ml PEVs group. RA-FLS, rheumatoid arthritis fibroblast-like synoviocytes; PEVs, platelet-derived extracellular vesicles.