Skip to main content
. 2021 Aug 10;15:665017. doi: 10.3389/fnins.2021.665017

TABLE 2.

Differences in diffusion MRI measures between multiple sclerosis patients and healthy controls.

Bundle Groups FAt (Mean ± SD) RDt (Mean ± SD) MDt (Mean ± SD) Free water fraction (Mean ± SD) AFDtot (Mean ± SD) NuFO (Mean ± SD)
Anterior CC RRMS 0.640 ± 0.017* 46 × 10–5 ± 2.2 × 10–5* 81 × 10–5 ± 1.5 × 10–5* 0.056 ± 0.017 0.307 ± 0.019* 1.152 ± 0.131*
HC 0.665 ± 0.023 43 × 10–5 ± 2.8 × 10–5 78 × 10–5 ± 1.9 × 10–5 0.049 ± 0.007 0.289 ± 0.011 1.044 ± 0.061
Posterior CC RRMS 0.685 ± 0.017* 40 × 10–5 ± 2.1 × 10–5* 77 × 10–5 ± 1.4 × 10–5* 0.070 ± 0.017 0.341 ± 0.015 1.246 ± 0.090
HC 0.703 ± 0.014 38 × 10–5 ± 1.7 × 10–5 75 × 10–5 ± 1.2 × 10–5 0.055 ± 0.010 0.327 ± 0.011 1.206 ± 0.076
Right cingulum RRMS 0.637 ± 0.025* 46 × 10–5 ± 3.1 × 10–5* 81 × 10–5 ± 2.0 × 10–5* 0.028 ± 0.006 0.299 ± 0.014 1.204 ± 0.136
HC 0.679 ± 0.017 41 × 10–5 ± 2.1 × 10–5 77 × 10–5 ± 1.4 × 10–5 0.023 ± 0.007 0.292 ± 0.008 1.450 ± 0.069
Left cingulum RRMS 0.667 ± 0.022 43 × 10–5 ± 2.7 × 10–5 78 × 10–5 ± 1.8 × 10–5 0.041 ± 0.009 0.298 ± 0.014* 1.183 ± 0.117
HC 0.684 ± 0.019 40 × 10–5 ± 2.4 × 10–5 77 × 10–5 ± 1.6 × 10–5 0.032 ± 0.009 0.284 ± 0.010 1.111 ± 0.076
Right fornix RRMS 0.709 ± 0.020 35 × 10–5 ± 2.7 × 10–5 73 × 10–5 ± 2.0 × 10–5 0.482 ± 0.066* 0.272 ± 0.026 1.067 ± 0.101
HC 0.705 ± 0.018 36 × 10–5 ± 2.6 × 10–5 74 × 10–5 ± 1.9 × 10–5 0.415 ± 0.046 0.274 ± 0.014 1.014 ± 0.104
Left fornix RRMS 0.698 ± 0.027 37 × 10–5 ± 4.0 × 10–5 74 × 10–5 ± 3.0 × 10–5 0.465 ± 0.091* 0.264 ± 0.028 1.019 ± 0.099
HC 0.696 ± 0.020 38 × 10–5 ± 2.6 × 10–5 75 × 10–5 ± 1.8 × 10–5 0.384 ± 0.034 0.269 ± 0.012 0.982 ± 0.104
Right IFOF RRMS 0.608 ± 0.021* 50 × 10–5 ± 2.5 × 10–5* 83 × 10–5 ± 1.7 × 10–5* 0.065 ± 0.018 0.309 ± 0.011 1.176 ± 0.112*
HC 0.642 ± 0.017 45 × 10–5 ± 2.1 × 10–5 80 × 10–5 ± 1.4 × 10–5 0.052 ± 0.011 0.297 ± 0.016 1.094 ± 0.059
Left IFOF RRMS 0.606 ± 0.020* 50 × 10–5 ± 2.5 × 10–5* 83 × 10–5 ± 1.7 × 10–5* 0.059 ± 0.011* 0.307 ± 0.013* 1.178 ± 0.113*
HC 0.645 ± 0.021 45 × 10–5 ± 2.5 × 10–5 80 × 10–5 ± 1.7 × 10–5 0.048 ± 0.010 0.291 ± 0.014 1.075 ± 0.060
Right ILF RRMS 0.599 ± 0.019* 51 × 10–5 ± 2.4 × 10–5* 84 × 10–5 ± 1.6 × 10–5* 0.061 ± 0.019 0.305 ± 0.011* 1.205 ± 0.134
HC 0.630 ± 0.018 47 × 10–5 ± 2.3 × 10–5 81 × 10–5 ± 1.5 × 10–5 0.049 ± 0.010 0.291 ± 0.015 1.090 ± 0.084
Left ILF RRMS 0.597 ± 0.018* 51 × 10–5 ± 2.3 × 10–5* 84 × 10–5 ± 1.5 × 10–5* 0.059 ± 0.014 0.305 ± 0.011* 1.211 ± 0.147
HC 0.630 ± 0.019 47 × 10–5 ± 2.4 × 10–5 81 × 10–5 ± 1.6 × 10–5 0.047 ± 0.010 0.287 ± 0.016 1.085 ± 0.087
Right SLF RRMS 0.607 ± 0.024* 50 × 10–5 ± 2.9 × 10–5* 83 × 10–5 ± 1.9 × 10–5* 0.010 ± 0.005 0.323 ± 0.014 1.433 ± 0.173
HC 0.637 ± 0.023 46 × 10–5 ± 2.8 × 10–5 81 × 10–5 ± 1.9 × 10–5 0.008 ± 0.003 0.313 ± 0.012 1.356 ± 0.111
Left SLF RRMS 0.597 ± 0.021* 51 × 10–5 ± 2.6 × 10–5* 84 × 10–5 ± 1.7 × 10–5* 0.011 ± 0.006 0.331 ± 0.015* 1.471 ± 0.167
HC 0.620 ± 0.015 48 × 10–5 ± 1.9 × 10–5 82 × 10–5 ± 1.3 × 10–5 0.008 ± 0.003 0.316 ± 0.012 1.378 ± 0.134
Right UF RRMS 0.554 ± 0.023* 56 × 10–5 ± 2.9 × 10–5* 88 × 10–5 ± 1.9 × 10–5* 0.030 ± 0.017 0.287 ± 0.010* 1.090 ± 0.166
HC 0.580 ± 0.028 53 × 10–5 ± 3.5 × 10–5 85 × 10–5 ± 2.3 × 10–5 0.023 ± 0.007 0.273 ± 0.016 0.949 ± 0.111
Left UF RRMS 0.543 ± 0.020* 58 × 10–5 ± 2.5 × 10–5* 89 × 10–5 ± 1.7 × 10–5* 0.029 ± 0.018 0.286 ± 0.014* 1.107 ± 0.176*
HC 0.569 ± 0.024 54 × 10–5 ± 2.9 × 10–5 86 × 10–5 ± 2.0 × 10–5 0.019 ± 0.006 0.271 ± 0.012 0.954 ± 0.095

AFDtot, total apparent fiber density; CC, corpus callosum; FAt, tissue fractional anisotropy; HC, healthy controls; IFOF, inferior fronto-occipital fasciculus; ILF, inferior longitudinal fasciculus; MDt (mm/s2), tissue mean diffusivity; NuFO, number of fiber orientation; RDt (mm/s2), tissue radial diffusivity; RRMS, relapsing-remitting multiple sclerosis; SD, standard deviation; SLF, superior longitudinal fasciculus; UF, uncinated fasciculus.

*statistically significant difference (p < 0.01).