Table 2.
Dose adjustment of immunosuppressants following bariatric surgery in transplant patients
| Organ transplanted | Study (first author, year of publication, reference) | Type of bariatric surgery | Number of patients | Immunosuppressive drug adjustment |
|---|---|---|---|---|
| Liver | Lin 2013[25] | Sleeve gastrectomy | 9 | No change |
| Lazzati 2015[31] | Not mentioned | 56 | No change | |
| Tsamalaidze 2018[36] | LSG | 12 | No significant change | |
| Kidney | Deogracias 2007[45] | Biliopancreatic diversion | 1 | No change |
| Rogers 2008[46] | Gastric bypass surgery | 2 | Increased dose for sirolimus, tacrolimus, and mycophenolate mofetil | |
| Szomstein 2010[37] | Laparoscopic surgery | 5 | Decreased dose of cyclosporine | |
| Arias 2010[41] | Laparoscopic gastric bypass | 5 | No change | |
| Golomb 2014[18] | Sleeve gastrectomy | 10 | Two increased dose of tacrolimus and one decreased (based on serum level) | |
| Gazzetta 2017[42] | Sleeve gastrectomy | 6 | No change | |
| Heart and kidney | Rex 1991[39] | Vertical banded gastroplasty | 1 | Changes based on serum level |
| Heart | Ablassmaier 2002[19] | Laparoscopic gastric banding | 1 | No change |
| Tsamalaidze 2017[32] | Laparoscopic robotic-assisted RYGB, and LSG | 2 | No change |
LSG=Laparoscopic sleeve gastrectomy; RYGB=Roux-en-Y gastric bypass