Table 4.
Effect of bariatric surgery on transplanted organ
| Organ transplanted | Study (first author, year of publication, reference) | Type of bariatric surgery | Number of patients | Evaluation method | Effects on transplanted organ |
|---|---|---|---|---|---|
| Liver | Duchini 2001[3] | RYGB | 2 | Liver biopsy | Reduced liver steatosis, absence of fibrosis and minimal portal inflammation |
| Al-Nowaylati 2013[38] | RYGB | 7 | Liver function test and albumin | The albumin level decreased in the patients who died in the post-RYGB period; however, the mean albumin level improved for the surviving patients. The mean AST, ALT, and total bilirubin levels declined postoperatively | |
| Lin 2013[25] | Sleeve gastrectomy | 9 | Liver function test | No episodes of graft rejection. At 3 months liver function tests remained stable | |
| Butte 2007[33] | Open sleeve gastrectomy (combined with Roux-en-Y biliary reconstruction) | 1 | Liver function test | Normal liver function test | |
| Tariciotti 2016[44] | Sleeve gastrectomy (combined with liver transplant) | 1 | Liver function test | Liver function test was normal 6 months after surgery, nondetectable HCV RNA level | |
| Osseis 2018[35] | Sleeve gastrectomy | 6 | Liver function test | Liver function tests values at last follow-up were not significantly different as compared to values before sleeve gastrectomy (paired t-test P>0.05) The median creatinine level decreased from a median 1.44 mg/dL (0.78-1.88) before the operation to 1.25 mg/dL, 12 months after operation (P=0.04) | |
| Kidney | Golomb 2014[18] | Sleeve gasterectomy | 10 | 24 h proteinuria and serum creatinine | Proteinuria decreased from median of 391 mg/24 h to 207 mg/24 h (P=0.05) |
| Dziodzio 2017[27] | Not mentioned | 20 | Not mentioned | Three out of four studies reported improvement in graft function in kidney transplant. One kidney graft loss after gastric bypass was reported | |
| Heart | Tsamalaidze 2017[32] | Laparoscopic robotic-assisted RYGB, and LSG | 2 | Trans esophageal echocardiography | No effect on transplanted organ |
| No signs of rejection |
RYGB=Roux-en-Y gastric bypass; ALT=Alanine aminotransferase; AST=Aspartate aminotransferase; HCV=Hepatitis C virus; LSG=Laparoscopic sleeve gastrectomy