TABLE 3.
IgG4 staining in eosinophilic esophagitis patients
| EoE patients by age group | Any positive IgG4 staining, no. (%)* | Esophageal level | IgG4 staining strong intensity, no. (%) | IgG4 staining lamina propria location, no. (%) | IgG4 staining epithelium location, no. (%) | IgG4 staining focal distribution, no. (%) |
|---|---|---|---|---|---|---|
| Pediatric, n = 16 | 8/16 (50) | Distal | 6/7 (86) | 7/7 (100) | 4/7 (57) | 4/7 (57) |
| Proximal | 5/8 (63) | 7/8 (88) | 4/8 (50) | 5/8 (63) | ||
| Adult, n = 15 | 7/15 (47) | Distal | 3/7 (43) | 5/7 (71) | 4/7 (57) | 5/7 (71) |
| Proximal | 2/5 (40) | 3/5 (60) | 2/5 (40) | 3/5 (60) |
EoE = eosinophilic esophagitis
Patients with EoE were significantly more likely to stain positively for IgG4 compared to children with reflux esophagitis or healthy controls (15/31 vs 0/8, P = 0.015).