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The Pharmacokinetic Parameters
| Parameters | Drugs | Free ORL/HA-CBZ | ORL/HA-CBZ/LPNs |
|---|---|---|---|
| Cmax (L/kg/h) | ORL | 11.6 ± 0.9 | 12.9 ± 1.1 |
| HA-CBZ | 18.9 ± 1.8 | 20.7 ± 1.9 | |
| T1/2 (h) | ORL | 0.9 ± 0.1 | 3.9 ± 0.6* |
| HA-CBZ | 1.5 ± 0.3 | 5.6 ± 0.9* | |
| AUC (mg/L·h) | ORL | 31.5 ± 2.1 | 129.8 ± 4.9* |
| HA-CBZ | 58.6 ± 2.9 | 198.4 ± 7.9* |
Notes: Data presented as means ± standard deviations; *P< 0.05 compared with free ORL/HA-CBZ.
