Table 3.

Univariable Cox Regression Analysis for Stratification by Clinicopathological or Molecular Parameters: The Association of FGFR3 and CDKN2A mRNA with OS and RFS

Parameter by Stratification	Overall Survival			Recurrence-Free Survival
	N	HR	p	N	HR	p
Age ≤ 71 years
FGFR3 high vs low	21 vs 19	0.22	0.013	4 vs 36	4.87	0.008
CDKN2A high vs low	22 vs 18	2.94	0.098	33 vs 7	3.88	0.189
Age > 71 years
FGFR3 high vs low	22 vs 18	1.13	0.790	8 vs 32	3.08	0.015
CDKN2A high vs low	26 vs 14	1.50	0.436	35 vs 5	1.01	0.988
KRT5 high
FGFR3 high vs low	25 vs 15	0.27	0.032	9 vs 31	4.92	<0.001
CDKN2A high vs low	21 vs 19	9.06	0.005	32 vs 8	1.71	0.388
KRT5 low
FGFR3 high vs low	18 vs 22	0.80	0.630	3 vs 37	2.78	0.183
FCDKN2A high vs low	27 vs 13	0.76	0.580	36 vs 4	1.95	0.518
KRT20 high
FGFR3 high vs low	26 vs 14	0.43	0.071	10 vs 30	3.43	0.007
CDKN2A high vs low	23 vs 17	3.03	0.049	36 vs 4	1.48	0.596
KRT20 low
FGFR3 high vs low	17 vs 23	0.52	0.226	2 vs 38	2.90	0.160
CDKN2A high vs low	25 vs 15	1.77	0.324	32 vs 8	1.90	0.391
MKI67 high
FGFR3 high vs low	25 vs 15	0.43	0.058	8 vs 32	2.99	0.014
CDKN2A high vs low	24 vs 16	2.13	0.141	35 vs 5	2.06	0.330
MKI67 low
FGFR3 high vs low	18 vs 22	0.40	0.129	4 vs 36	4.59	0.022
CDKN2A high vs low	24 vs 16	2.46	0.164	33 vs 7	1.34	0.700
Instillation
FGFR3 high vs low	21 vs 20	0.35	0.061	6 vs 35	2.61	0.047
CDKN2A high vs low	22 vs 19	2.67	0.092	35 vs 6	1.62	0.434
No instillation
FGFR3 high vs low	22 vs 17	0.81	0.623	6 vs 33	5.44	0.003
CDKN2A high vs low	26 vs 13	1.93	0.241	33 vs 6	2.18	0.454

Note: Significant values are in bold.

Abbreviation: HR, hazard ratio.