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. 2021 Aug 24;16(8):e0256029. doi: 10.1371/journal.pone.0256029

Table 4. Projected number of study participants required for future clinical trial (single site).

Two Independent Groups
MRI Measure	80% Power			90% Power
MRI Measure	5% Difference	10% Difference	20% Difference	5% Difference	10% Difference	20% Difference
Volume [ml]	2142	538	136	2868	718	182
PVI [ml/kg]	768	198	50	1026	264	68
ADC [mm²/s]	258	128	16	346	170	20
MTR	722	182	46	964	242	60
Within Subject Variation
MRI Measure	80% Power			90% Power
MRI Measure	5% Difference	10% Difference	20% Difference	5% Difference	10% Difference	20% Difference
Volume [ml]	40	12	5	53	15	5
PVI [ml/kg]	36	11	4	48	14	5
ADC [mm²/s]	18	10	3	23	13	3
MTR	128	16	6	170	21	7