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. 2021 Aug 12;17(8):e1009529. doi: 10.1371/journal.pgen.1009529

Fig 4. Mot1 removal partially restores wild-type transcription in Med16-AID cells.

Fig 4

(A) Western blots showing the kinetics of Mot1-AID and Med16-AID upon 3-IAA treatment of double-degron cells. (B) Boxplots of log2 fold changes in nsRNA levels of transcripts produced from Med16-down and Med16-up genes for the Med16-AID and Mot1/Med16-AID 3-IAA versus DMSO comparisons. Statistical differences between groups were assessed by pairwise Wilcoxon rank-sum test with Holm correction for multiple testing. (C) Average plots of TBP ChEC-seq signal (≤80 bp fragments) from Med16-AID cells treated with 3-IAA or DMSO and free MNase from WT cells (MNase) in a 2 kb window centered around the TSSs of Med16-down and Med16-up genes.