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. 2020 Aug 19;115(2):270–272. [Article in Portuguese] doi: 10.36660/abc.20190780

Figure 1. – Structured octet for the treatment of hypertension.

Figure 1

THIAZ: thiazide-type/thiazide-like diuretic; RASI: renin angiotensin system inhibitor; CCB: calcium-channel blocker; βB: Beta-blocker; α2A: central alpha-2 agonist; α1B: alpha-1 adrenergic blocker; VD: direct vasodilator. *When BP control is not achieved with THIAZ, RASI and CCB, and the THIAZ is hydrochlorothiazide, substitute this latter drug by a long-acting THIAZ (chlortalidone or indapamide). If glomerular filtration rate <30 mL/min, substitute THIAZ by a loop diuretic, such as furosemide. †If spironolactone is not tolerated, particularly due to anti-androgenic side effects, consider substituting this drug by amiloride. ‡βB is indicated as the first choice for the initial treatment when there are specific indications, such as angina, post-myocardial infarction, heart failure, arrhythmia or heart rate control.