Figure 6. Deficiency of m¹G37 induces gene expression similar to that of the bacterial stringent response.

(A) A set of genes published previously by Gourse et al. (Sanchez-Vazquez et al., 2019), whose steady-state RNA levels changed more than 2-fold upon induction of the stringent response by RelA over-expression (down n = 401 genes, up n = 321 genes, other = 3036 genes). Using these same sets of genes, the ratio of RNA levels in trmD-deg and trmD-cont strains upon ClpXP induction are shown. (B) Changes in expression in genes involved in amino acid biosynthesis (n = 89), genes encoding ribosomal proteins (n = 47), and other genes.