Figure 2.

Exposure to S1SP of SARS-CoV-2 induces alveolar and systemic “cytokine storm” in BALF (A) and serum (B) 72 h after instillation.means ± SE; n = 5 mice/group; *P < 0.05; **P < 0.01, ***P < 0.001; ****P < 0.0001 with one-way ANOVA followed by Tukey’s in log-transformed values. BALF, bronchoalveolar lavage fluid; MCP, monocyte chemoattractant protein; SARS-CoV-2, severe acute respiratory syndrome coronavirus-2; SP, spike protein; VEH, vehicle; S1SP, subunit 1 of spike protein; KC, keratinocytes-derived chemokine; MIP1α, macrophage inflammatory protein 1-alpha; MIG, gamma interferon; IP 10, interferon gamma-induced protein 10.