Table 2.
Genes that are causally associated with the risk of CAD.
| Population | eQTL | Probe ID | CHR | Gene | Top SNP | p_GWAS | p_eQTL | b_SMR | p_SMR | p_HEIDI |
|---|---|---|---|---|---|---|---|---|---|---|
| European | Artery coronary | ENSG00000144426.14 | 2 | NBEAL1 | rs2351524 | 0.4860822 | 2.77E-09 | -0.314 | 8.42E-06 | 0.533 |
| East Asian | Artery aorta | ENSG00000272750.1 | 1 | RP11-378J18.8 | rs2291832 | 3.672E-10 | 2.01E-30 | -0.161 | 3.79E-08 | 4.54E-04 |
| ENSG00000112137.12 | 6 | PHACTR1 | rs9349379 | 1.177E-13 | 1.68E-11 | -0.616 | 6.12E-07 | 1.72E-07 | ||
| ENSG00000272379.1 | 6 | RP1-257A7.5 | rs9349379 | 1.177E-13 | 4.01E-10 | -0.576 | 1.72E-06 | NA | ||
| ENSG00000180263.9 | 12 | FGD6 | rs7954260 | 8.589E-08 | 1.49E-17 | 0.228 | 5.70E-06 | 0.198 | ||
| ENSG00000136378.10 | 15 | ADAMTS7 | rs7173743 | 2.741E-08 | 4.94E-13 | -0.329314 | 1.06E-05 | 0.00590 | ||
| Artery coronary | ENSG00000272750.1 | 1 | RP11-378J18.8 | rs17163358 | 1.854E-09 | 2.78E-10 | -0.202 | 1.32E-05 | 0.00121 | |
| Blood | ENSG00000089169.10 | 12 | RPH3A | rs7979186 | 5.75E-09 | 7.75E-55 | -0.150 | 4.95E-08 | 6.11E-04 | |
| Heart atrial appendage | ENSG00000272750.1 | 1 | RP11-378J18.8 | rs61824331 | 3.534E-08 | 3.07E-20 | -0.172 | 2.20E-06 | 0.0129 | |
| ENSG00000175164.9 | 9 | ABO | rs643434 | 5.315E-08 | 5.00E-22 | 0.170 | 2.20E-06 | 2.07E-05 | ||
| Heart left ventricle | ENSG00000272750.1 | 1 | RP11-378J18.8 | rs2291832 | 3.672E-10 | 1.41E-23 | -0.155 | 1.08E-07 | 3.71E-04 | |
| ENSG00000175164.9 | 9 | ABO | rs657152 | 6.34E-09 | 6.84E-20 | 0.214 | 9.14E-07 | 1.053E-05 |