Table 9.
Main pharmacokinetic parameters of the three analytes in the plasma of rats after the oral administration of SE or SEP extract (n = 6).
| Data | Euphorbia factor L1 | Euphorbia factor L2 | Euphorbia factor L3 | |||
|---|---|---|---|---|---|---|
| SE | SEP | SE | SEP | SE | SEP | |
| AUC (0-t) (μg·h·L−1) | 1703.73 ± 554.18 | 1391.45 ± 663.03 | 4391.97 ± 1596.69 | 3192.79 ± 1409.02 | 6381.91 ± 1428.34∗ | 4100.05 ± 1741.94∗ |
| AUC (0-∞) (μg·h·L−1) | 2883.63 ± 2458.81 | 1416.66 ± 662.13 | 5382.56 ± 1370.29∗ | 3230.99 ± 1415.46∗ | 9463.33 ± 6415.46 | 4208.31 ± 1769.18 |
| MRT (0-t) (h) | 17.80 ± 2.16 | 16.78 ± 3.56 | 17.04 ± 4.18 | 15.71 ± 2.18 | 18.83 ± 2.33 | 16.10 ± 2.56 |
| MRT (0-∞) (h) | 22.57 ± 3.87 | 17.79 ± 3.92 | 21.73 ± 4.31∗ | 16.29 ± 2.42∗ | 24.47 ± 7.51 | 17.50 ± 3.27 |
| T1/2z (h) | 9.53 ± 6.43 | 8.42 ± 2.67 | 9.57 ± 4.32 | 7.42 ± 1.05 | 9.35 ± 4.91 | 8.46 ± 2.19 |
| Tmax (h) | 11.33 ± 1.63∗∗ | 6.67 ± 2.07∗∗ | 11.33 ± 1.63∗ | 8.00 ± 2.53∗ | 11.33 ± 1.63∗ | 8.00 ± 2.53∗ |
| Vz/F (L·kg−1) | 220467.01 ± 146342.43 | 345882.41 ± 248756.73 | 85495.40 ± 51708.11 | 117516.85 ± 57982.30 | 61277.19 ± 49305.43∗ | 108497.33 ± 83949.46∗ |
| CLz/F L·(h·kg−1) | 15457.44 ± 8978.23 | 27871.15 ± 18174.36 | 5927.25 ± 1697.04 | 10922.36 ± 5049.21 | 3993.88 ± 1591.83 | 8591.23 ± 4521.52 |
| Cmax (μg·L−1) | 102.68 ± 34.75 | 91.39 ± 47.39 | 281.32 ± 105.93 | 218.53 ± 111.66 | 381.33 ± 139.59 | 327.20 ± 147.33 |
SE group compared with SEP group, ∗p < 0.05, ∗∗p < 0.01.