Table 1.
Baseline gut microbiota or bacterial metabolite characteristics of responders and nonresponders.
| Treatment | Responders | Nonresponders | Predictors | ||
|---|---|---|---|---|---|
| Increase | Decrease | Increase | Decrease | ||
| Exercise |
Lanchospiraceae bacterium Streptococcus mitis Bacteroides SCFAs GABA |
Bacteroides xylanisolvens Alistipes shahii Prevotella copri BCAAs |
Alistipes shahii Detrimental metabolites |
Alistipes putredinis Ruminococcus gnavus GABA SCFAs |
Bacteroides xylanisolvens Bacteroides cellulosilyticus GABA |
|
| |||||
| FMT |
Subdoligranulum variabile
Dorea longicatena |
Eubacterium ventriosum
Ruminococcus torques |
Ruminococcus torques | Low baseline diversity Subdoligranulum variabile |
|
|
| |||||
| Barley bread | Prevotella species | Bacteroides species | Prevotella copri | ||
|
| |||||
| Drugs | |||||
|
| |||||
| Metformin | Imidazole propionate | Imidazole propionate | Imidazole propionate | ||
|
| |||||
| Acarbose |
Bacteroides UDCA PBA/SBA ratio |
LCA and DCA 12-α OH/non-12α OH BA ratio |
Prevotella | Bacteroides/Prevotella | |
SCFAs: short-chain fatty acids; GABA: γ-aminobutyric acid; BCAAs: branched-chain amino acids; FMT: fecal microbiota transplantation; UDCA: ursodeoxycholic acid; PBA: primary bile acids; SBA: secondary bile acids; LCA: lithocholic acid; DCA: deoxycholic acid; BA: bile acid.