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. Author manuscript; available in PMC: 2021 Aug 25.
Published in final edited form as: Science. 2021 Jan 22;371(6527):415–419. doi: 10.1126/science.aba0542

Fig. 4. Trade-offs between the alternative and reference alleles in the galactose pathway.

Fig. 4.

(A) Growth rates of allele replacement strains (n = 6) with all three reference (right) or all three alternative (left) alleles in galactose as a sole carbon source. (B) As in (A), but for cells grown in glucose. (C) Growth curves of allele replacement strains with all three alternative (red) or reference (gray) galactose alleles in mixed glucose and galactose medium. OD600, optical density at 600 nm. (D) Allele-specific expression of the galactose genes from a diploid hybrid (CBS2888xBY) strain grown in glucose.