Table 1.
Promising cancer-specific functional targets for breast cancer therapy
| Genes | Gene ID (NCBI) | Functions | Expression data in breast cancer cases (%)a | Expression data in normal human organs | Ref. |
|---|---|---|---|---|---|
| MELK | 9833 | Serine/threonine kinase | 26/34 (76.5%) | Testis | [33] |
| TOPK | 55872 | Serine/threonine kinase | 31/40 (77.5%) | Testis, thymus, spleen, | [34] |
| BIG3 | 57221 | Anchoring scaffold protein | 26/41 (63.4%) | Pancreas, brain | [35] |
| C12orf32 | 83695 | DNA damage response | 24/78 (30.8%) | Testis, prostate | [36] |
| DTL | 51514 | Mitotic cell regulator | 54/79 (68.4%) | Testis, placenta thymus | [37] |
| GALNT6 | 11226 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase | 30/81 (37.0%) | Placenta, pancreas, stomach, | [38] |
| GPATCH2 | 55105 | Enhancer of ATPase activity | 17/42 (40.5%) | Testis, | [39] |
| GPSM2 | 29899 | Modulator of G proteins activation | 16/22 (72.7%) | Brain, lung | [40] |
| KIF2C | 10112 | Mitotic cell regulator | 47/63 (74.6%) | Testis, bone marrow, thymus | [41] |
| PRC1 | 9055 | Mitosis regulator (cytokinesis) | 37/59 (62.7%) | Testis, bone marrow, thymus | [42] |
| RQCD1 | 9125 | Signal transduction regulator | 11/14 (78.6%) | Testis | [43] |
| UBE2T | 09089 | E2 Ubiquitin ligase | 41/50 (80.2%) | Testis, skeletal muscle | [44] |
aBreast cancer patients who show the upregulation (>5-fold) of each gene in breast cancer cells compared with normal breast epithelial cells [27]