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. 2021 Jul 16;66(9):887–899. doi: 10.1038/s10038-021-00960-8

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© The Author(s) 2021

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Fig. 3 — Germline variants in CDH1 gene identified in GC patients. A histogram of non-silent germline variants of CDH1 gene identified in a recent trans-ethnic study [32]. Colors of the circles represent ethnicities of the patients as indicated. Circles with black rims represent cases of DGC. * and # represent CDH1 variants that were predicted as damaging in silico and found in clinical HDGC families, respectively