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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Curr Opin Chem Biol. 2021 Mar 8;63:57–67. doi: 10.1016/j.cbpa.2021.02.003

Figure 2: Molecular mechanisms associated with BPTF function.

Figure 2:

A) Reported interactions of BPTF/FAC1. Histone proteins shown in blue, transcriptional regulators in red, antioxidant response proteins in cyan, chromatin regulators in magenta, and NURF subunits in green. B) Mechanistic role of MITF and BPTF in melanoma. MITF regulates the expression of BPTF and associates with NURF to co-regulate the expression of cell-cycle-regulating genes. C) BPTF drives c-Myc expression and binds to c-Myc to facilitate its transcriptional activity. Supplementary Table 1 is provided as a resource for additional direct BPTF genes in various disease states.