Table 2.
Predicted geometric mean (95% confidence interval, 95% CI) of weight, waist circumference and body fat mass, as well as predicted mean (95% CI) of proportion fat mass by tertile of total PFOSserum concentrations; and ratios of geometric mean or difference in mean across the comparison groups in women with the second the third tertiles vs. the lowest tertile as reference, from linear mixed-effect models.a
| Weight | |||||
|---|---|---|---|---|---|
| Geometric mean (95% CI), kg | Ratio of geometric mean (95% CI)b | ||||
| Tertile of total PFOS concentrationsc | |||||
| Tertile 1 | Tertile 2 | Tertile 3 | Tertile 2 vs. 1 | Tertile 3 vs. 1 | |
| Baseline | 69.6 (67.9, 71.3) | 73.1 (71.4, 74.8) | 73.9 (72.2, 75.7) | 1.05 (1.02, 1.08) | 1.06 (1.03, 1.09) |
| Year 5 | 69.9 (68.3, 71.6) | 73.3 (71.5, 75.0) | 75.2 (73.4, 77.0) | 1.05 (1.02, 1.08) | 1.07 (1.04, 1.11) |
| Year 10 | 70.1 (68.4, 71.8) | 73.2 (71.5, 75.0) | 76.0 (74.2, 77.8) | 1.04 (1.02, 1.07) | 1.08 (1.05, 1.12) |
| Year 15 | 69.2 (67.6, 70.9) | 72.2 (70.5, 74.0) | 75.0 (73.2, 76.8) | 1.04 (1.01, 1.07) | 1.08 (1.05, 1.11) |
| Waist circumference | |||||
| Geometric mean (95% CI), cm | Ratio of geometric mean (95% CI)b | ||||
| Tertile of total PFOS concentrationsc | |||||
| Tertile 1 | Tertile 2 | Tertile 3 | Tertile 2 vs. 1 | Tertile 3 vs. 1 | |
| Baseline | 83.7 (82.2, 85.1) | 86.4 (85.0, 87.9) | 87.3 (85.8, 88.9) | 1.03 (1.01, 1.05) | 1.04 (1.02, 1.07) |
| Year 5 | 85.1 (83.6, 86.5) | 87.8 (86.3, 89.3) | 89.3 (87.8, 90.9) | 1.03 (1.01, 1.05) | 1.05 (1.03, 1.07) |
| Year 10 | 86.4 (84.9, 87.9) | 89.1 (87.5, 90.6) | 91.0 (89.4, 92.6) | 1.03 (1.01, 1.05) | 1.05 (1.03, 1.08) |
| Year 15 | 87.4 (85.9, 88.9) | 89.6 (88.1, 91.2) | 91.5 (89.9, 93.1) | 1.03 (1.01, 1.05) | 1.05 (1.03, 1.07) |
| Body fat mass | |||||
| Geometric mean (95% CI), kg | Ratio of geometric mean (95% CI)b | ||||
| Tertile of total PFOS concentrationsc | |||||
| Tertile 1 | Tertile 2 | Tertile 3 | Tertile 2 vs. 1 | Tertile 3 vs. 1 | |
| Baseline | 25.2 (24.2, 26.3) | 27.2 (26.1, 28.3) | 27.9 (26.8, 29.0) | 1.08 (1.03, 1.13) | 1.10 (1.05, 1.16) |
| Year 5 | 25.3 (24.3, 26.3) | 27.3 (26.3, 28.4) | 28.3 (27.2, 29.5) | 1.08 (1.03, 1.13) | 1.12 (1.07, 1.17) |
| Year 10 | 25.4 (24.4, 26.4) | 27.5 (26.4, 28.6) | 28.8 (27.6, 29.9) | 1.08 (1.03, 1.13) | 1.13 (1.08, 1.19) |
| Year 15 | 25.3 (24.3, 26.4) | 27.5 (26.4, 28.6) | 29.0 (27.9, 30.2) | 1.08 (1.04, 1.14) | 1.15 (1.09, 1.20) |
| Proportion fat mass | |||||
| Mean (95% CI), % | Difference in mean (95% CI), % | ||||
| Tertile of total PFOS concentrationsc | |||||
| Tertile 1 | Tertile 2 | Tertile 3 | Tertile 2 vs. 1 | Tertile 3 vs. 1 | |
| Baseline | 40.6 (39.9, 41.3) | 41.8 (41.1, 42.5) | 42.4 (41.7, 43.1) | 1.24 (0.46, 2.01) | 1.81 (1.01, 2.61) |
| Year 5 | 40.8 (40.1, 41.5) | 42.1 (41.4, 42.8) | 42.7 (42.0, 43.4) | 1.28 (0.52, 2.04) | 1.92 (1.13, 2.71) |
| Year 10 | 41.0 (40.3, 41.7) | 42.3 (41.6, 43.1) | 43.1 (42.4, 43.8) | 1.92 (1.13, 2.71) | 2.03 (1.23, 2.83) |
| Year 15 | 41.1 (40.4, 41.9) | 42.5 (41.8, 43.3) | 43.2 (42.5, 43.9) | 1.40 (0.61, 2.19) | 2.08 (1.27, 2.90) |
Models were adjusted for age at baseline, race, study site, education, financial strain, smoking status, passive smoking, alcohol consumption, total calorie intake, physical activity, and menopausal status.
Weight, waist circumference, and body fat mass were log-transformed to ensure normality; thus ratios of geometric mean (95% CI) were calculated.
Medians (ranges) of total PFOS concentrations by tertiles were 14.8 (2.0, 20.1) ng/mL for tertile 1, 25.1 (20.2, 30.9) ng/mL for tertile 2, and 42.9 (31.0, 376.0) ng/mL for tertile 3.