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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Curr Opin Chem Biol. 2021 Apr 11;63:132–144. doi: 10.1016/j.cbpa.2021.03.002

Figure 2.

Figure 2.

Representative co-crystal structures of Kme reader antagonist binding. (a) EED226 inserts into EED (PDB ID: 5WUK); (b) BI-9321 utilizes fragment linking to engage in multiple contacts throughout NSD3PWWP1 (PDB ID: 6G2O); (c) VinSpinIn binds Tudor domains 1 and 2 of SPIN1 through a cavity-insertion binding mode (PDB ID: 6I8B); (d) UNC3866 creates an extended PPI with CBX7 chromodomain (PDB ID: 5EPJ).